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Updated: Apr 10, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K

Nighttime central blood pressure and left ventricular hypertrophy in non-dialysis chronic kidney disease: a

Ruoyan Deng1, Qiong Li1, Cheng Chen2

  • 1Division of Nephrology, Department of Medicine, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.

American Journal of Hypertension
|April 8, 2026
PubMed

Insights

Nighttime central systolic blood pressure (SBP) is more strongly linked to left ventricular hypertrophy (LVH) in chronic kidney disease (CKD) patients than brachial SBP. This finding highlights central pressure

Area of Science:

  • Cardiology
  • Nephrology
  • Hypertension Research

Background:

  • Nocturnal hypertension is a known risk factor for left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD).
  • Central blood pressure measurements offer a more accurate reflection of cardiovascular system load compared to traditional brachial measurements.
  • The specific relationship between nighttime central systolic blood pressure (SBP) and LVH in CKD patients has not been previously established.

Purpose of the Study:

  • To investigate the association between nighttime central systolic blood pressure (SBP) and left ventricular hypertrophy (LVH) in non-dialysis chronic kidney disease (CKD) patients.
  • To compare the predictive value of nighttime central SBP versus nighttime brachial SBP for LVH in this population.

Main Methods:

  • A multicenter retrospective study involving 3198 non-dialysis CKD patients.
  • Ambulatory blood pressure monitoring was conducted using the Mobil-O-Graph PWA device.
  • Patients were categorized into four nocturnal hypertension patterns based on nighttime brachial SBP and central SBP (c2SBP) thresholds; logistic regression and net reclassification improvement were employed for analysis.

Main Results:

  • 15% of patients had LVH, and 30.9% exhibited nocturnal central hypertension. Both conditions increased with declining renal function.
  • LVH risk escalated with higher nighttime c2SBP levels.
  • Nighttime c2SBP showed a stronger correlation with LVH than nighttime brachial SBP, with consistent nocturnal hypertension significantly increasing LVH risk (aOR=2.660).

Conclusions:

  • Nighttime central SBP is more significantly associated with LVH in non-dialysis CKD patients compared to nighttime brachial SBP.
  • Central blood pressure monitoring may offer improved risk stratification for cardiovascular complications in CKD.
  • Further prospective studies are warranted to confirm the prognostic implications of nighttime central SBP in CKD.
Abstract

Keywords:
chronic kidney diseasehypertensionleft ventricular hypertrophynighttime central blood pressure

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