Related Experiment Video
Updated: Apr 10, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
14.0K
Castration Resistance Accelerates Prostate Cancer Kinetics.
Sheila Jonnatan1, Luka Cavka1, Angelo M De Marzo1
1Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
The Prostate
|April 8, 2026
Summary
Prostate cancer progresses faster when it becomes castration-resistant. This accelerated growth, measured by prostate-specific antigen doubling time (PSADT), may impact survival for patients with indolent disease.
Area of Science:
- Oncology
- Urology
- Cancer Research
Background:
- Prostate cancer is often indolent, allowing long survival.
- Castration therapy has been used for over 70 years.
- The impact of castration resistance on prostate cancer progression rate is not well understood.
Purpose of the Study:
- To quantify the change in prostate-specific antigen doubling time (PSADT) before and after castration resistance develops.
- To investigate the relationship between PSADT and overall survival in castration-resistant prostate cancer (CRPC).
Main Methods:
- Longitudinal analysis of PSADT in 40 prostate cancer patients before and after castration resistance.
- Correlation analysis of CR-PSADT with overall survival and Ki-67 index in a separate cohort of 36 metastatic CRPC patients.
Main Results:
- Castration-resistant prostate cancer (CR-PSADT) showed a significantly shorter median PSADT (2.6 months) compared to castration-naïve prostate cancer (CN-PSADT) (5.8 months).
- CR-PSADT positively correlated with CN-PSADT and overall survival.
- A negative correlation was found between CR-PSADT and the Ki-67 proliferation index in metastatic tumor biopsies.
Conclusions:
- Castration resistance markedly accelerates prostate cancer kinetics.
- This accelerated progression may negatively impact survival, particularly if androgen deprivation therapy (ADT) is initiated prematurely in indolent cases.
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