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Updated: Apr 10, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Person-environment interaction processes in frailty: a scoping review.
Junjie Zhang1, Xiayu Wang2, Paul S F Yip1,3
1Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong SAR, China.
Person-environment interactions are crucial for understanding frailty in older adults. This review proposes a new model showing how adaptation to environmental stress across different spatial levels impacts health outcomes.
Area of Science:
- Gerontology
- Environmental Psychology
- Public Health
Background:
- Frailty is an age-related condition increasing vulnerability to stressors.
- Person-environment (P-E) interactions influencing frailty are underexplored.
- Understanding P-E dynamics is vital for older adult health.
Purpose of the Study:
- To synthesize current knowledge on P-E interactions associated with frailty.
- To explore the relevance of the COntext Dynamics in Aging (CODA) framework.
- To propose a refined model of P-E interactions in frailty.
Main Methods:
- Systematic literature search (PubMed, Web of Science, CINAHL) from 2001-2024.
- Included 130 studies out of 2,991 screened articles.
- Extracted data on study characteristics, environment/frailty definitions, and conceptual models.
Main Results:
- The COntext Dynamics in Aging (CODA) framework is relevant to frailty research.
- Identified diverse environmental indicators across CODA domains.
- Proposed a refined model of dynamic interplay between individual adaptation and environmental stress, including a spatial-differential perspective ('hierarchical stair' principle).
Conclusions:
- Emphasizes dynamic P-E interactions across spatial levels for adaptation and stress.
- Highlights scarcity of studies on interaction processes and spatial dynamics.
- Proposes a heuristic model for future hypothesis-driven research, advocating for empirical testing of multilevel approaches.
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