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Frailty and menopause: A gateway to healthy aging
Aitana Monllor-Tormos1, Arturo Artero2, Miguel-Ángel García-Pérez3
1Service of Obstetrics and Gynecology Hospital Universitario La Fe, Valencia, Spain.
Maturitas
|April 8, 2026
Summary
This review explores how hormonal changes during menopause increase frailty risk in women. Lifestyle factors like diet and exercise show promise in mitigating frailty, promoting healthy aging.
Area of Science:
- Gerontology and Women's Health
Background:
- Frailty is a decline in physiological reserves, increasing vulnerability and adverse health outcomes.
- Women exhibit higher frailty risk than men, with menopause exacerbating susceptibility.
Purpose of the Study:
- To review hormonal factors contributing to frailty in women during menopause.
- To examine the roles of steroid-related pathways (estrogens, androgens, vitamin D) in midlife frailty.
Main Methods:
- Literature review integrating evidence on hormonal changes and frailty.
- Focus on steroid hormone pathways and vitamin D metabolism.
Main Results:
- Menopause-associated hormonal shifts may increase frailty risk.
- Limited evidence suggests menopausal hormone therapy might offer protection.
- Healthy diet and physical activity are effective in mitigating frailty.
Conclusions:
- Hormonal factors, particularly steroid-related pathways, play a role in menopausal frailty.
- Lifestyle interventions are crucial for counteracting frailty during and after menopause.
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