Related Experiment Video

Updated: Apr 10, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.9K

Cognitive and Emotional Predictors of Health-Related Quality of Life in Pediatric-Onset Multiple Sclerosis

Noa Gur1, Ayal Rozenberg2, Dan Hoofien3

  • 1Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel; The Neuropsychological Unit, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel.

Pediatric Neurology
|April 8, 2026
PubMed

Insights

Pediatric multiple sclerosis impacts children

Area of Science:

  • Pediatric Neurology
  • Quality of Life Research

Background:

  • Pediatric-onset multiple sclerosis (POMS) significantly affects children's health-related quality of life (HRQOL).
  • Understanding HRQOL predictors is vital for developing effective interventions.
  • This study investigated cognitive and emotional factors influencing HRQOL in children with POMS.

Purpose of the Study:

  • To identify cognitive and emotional predictors of HRQOL in children with POMS.
  • To compare children's and parents' perspectives on HRQOL determinants.
  • To inform clinical strategies for improving HRQOL in pediatric MS patients.

Main Methods:

  • Cross-sectional study of 30 children with POMS (mean age 15.76).
  • Assessed HRQOL (self- and parent-report), cognitive function (processing speed, attention, memory), and psychological status (depression, anxiety).
  • Used multiple regressions and correlations to analyze predictors of HRQOL.

Main Results:

  • School functioning was the most impacted HRQOL domain.
  • Child-reported HRQOL was primarily predicted by anxiety and depression.
  • Parent-reported HRQOL was influenced by cognitive factors (processing speed, attention) and depression.

Conclusions:

  • Children's HRQOL is significantly linked to their emotional state (anxiety, depression).
  • Parents' perceptions of HRQOL are more influenced by cognitive functioning.
  • Integrated assessment of emotional and cognitive factors is crucial for enhancing HRQOL in POMS.
Abstract

Keywords:
AnxietyCognitive functioningDepressionHealth-related quality of life (HRQOL)Pediatric-onset multiple sclerosis (POMS)

More Related Videos

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood08:09

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood

Published on: February 11, 2017

12.3K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.7K

Related Concept Videos

Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
5.6K
The Influence of Cognition on Affect01:29

The Influence of Cognition on Affect

Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
308
Socioemotional Development during Infancy01:30

Socioemotional Development during Infancy

Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
1.3K
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
1.0K
Dimensions of Health and Illness01:21

Dimensions of Health and Illness

The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
12.0K