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BiFUSE-UNet: a novel dual-encoder enhanced TransUNet for polyp segmentation
Wenli Lei1,2, Tianwu Yao1,2, Rui Feng1
1Yan'an University, Yan'an, Shaanxi 716000, People's Republic of China.
Biomedical Physics & Engineering Express
|April 8, 2026
Summary
Accurate polyp segmentation in medical images is crucial for early cancer detection. BiFuse-UNet, a novel dual-encoder TransUNet, significantly improves polyp segmentation accuracy, outperforming existing methods.
Area of Science:
- Medical Imaging
- Computer Vision
- Artificial Intelligence
Background:
- Polyps are abnormal mucosal tissue growths with potential for malignant transformation.
- Accurate segmentation of polyps in medical images is challenging due to morphological heterogeneity, blurry boundaries, and data limitations.
- Early detection and intervention for polyps can prevent malignant progression.
Purpose of the Study:
- To develop an advanced deep learning model for accurate polyp segmentation in medical images.
- To address the challenges of polyp segmentation, including appearance variability and boundary ambiguity.
- To improve the detection of subtle and early-stage polyps with atypical morphology.
Main Methods:
- Introduction of BiFuse-UNet, a novel dual-encoder TransUNet architecture with a bidirectional fusion mechanism.
- Integration of a multi-axis attention module (MaxViT block) for multi-scale feature extraction and long-range dependency capture.
- Incorporation of a Merge fusion module with Coordinate Attention and SaE block for enhanced local feature perception.
- Utilization of a Biformer module to balance global semantics and local details for improved segmentation.
Main Results:
- BiFuse-UNet achieved state-of-the-art segmentation performance on the Kvasir-SEG dataset.
- The model outperformed seven existing methods in Dice coefficient, Recall, Precision, and IoU metrics.
- BiFuse-UNet effectively handled morphological heterogeneity, blurry boundaries, and background interference.
Conclusions:
- BiFuse-UNet demonstrates superior accuracy in pixel-level polyp segmentation.
- The proposed architecture offers a robust solution for challenging polyp segmentation tasks.
- This advancement contributes to more reliable early detection and diagnosis of polyps.

