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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Updated: Apr 10, 2026

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

Intertwining Intravascular Imaging and Transcriptomics to Identify Responsiveness to PCSK9 Inhibitor Therapy

Farouc A Jaffer¹

¹Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.

JACC. Cardiovascular Imaging

|April 8, 2026

Summary

No abstract available in PubMed .

Keywords:

PCSK9 inhibitors coronary atherosclerosis intravascular imaging transcriptomics

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