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Updated: Apr 10, 2026

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Pigmentary Disorders in Skin of Color: Histopathologic Overview
Miguel A Aristizabal-Torres1, Oluwakemi Onajin2, Olayemi Sokumbi3
1Department of Dermatology, Mayo Clinic, Jacksonville, FL 32224, USA.
Abstract:
Disorders of pigmentation in individuals with skin of color (SOC) are frequently encountered in dermatologic practice and often pose diagnostic and therapeutic challenges. These conditions can lead to significant psychosocial distress and reduced quality of life. This review provides an in-depth analysis of pigmentary disorders in SOC, emphasizing their clinical manifestations, histopathologic features, and pathophysiologic mechanisms. Additionally, the review highlights pigmentary mimics of disorders, with inflammatory or systemic associations, and emphasizes histopathologic characterization to improve diagnostic precision and support patient-centered care.
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