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Disease insights from brain somatic mosaicism

Changuk Chung1,2, Rahul Nedunuri1,2, Joseph G Gleeson3,4

  • 1Department of Neurosciences, University of California San Diego, La Jolla, CA, 92037, USA.

Experimental & Molecular Medicine
|April 8, 2026
PubMed
Summary

Brain somatic mosaicism (BSM) involves genetic variations in brain cells, offering insights into neurodevelopmental and neurodegenerative diseases. Studying these mosaic variants (MVs) aids in understanding brain aging and disease mechanisms.

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