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Updated: Apr 10, 2026

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Published on: June 2, 2014
Focus on migraine prodrome: what should clinicians know?
Monica Ngo1, Mohammad Ismail Ehsani-Nia, Jessica Ailani
1MedStar Georgetown University Hospital, Washington, DC, USA.
Purpose Of Review:
The prodromal phase of migraine is highly prevalent and can be very disabling. In this review, we seek to understand the clinical features of prodrome and its underlying pathophysiology. Our aim is to assess the impact of early treatment of migraine during the prodromal phase.
Recent Findings:
A recent phase 3 trial showed ubrogepant is effective at preventing migraine during the prodromal phase. Further studies have shown it is effective in reducing disabling symptoms of the prodrome itself and positive patient reported outcomes.
Summary:
The prodromal phase of migraine presents the earliest opportunity to treat migraine and prevent disability. Studies have shown that the use of medications during this phase of migraine to be effective with recent studies showing ubrogepant is effective when used during prodrome.
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Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Equilibrium and Balance

