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Updated: Apr 10, 2026
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Published on: July 5, 2021
Outcomes Following en Bloc Resection of Olfactory Neuroblastoma
Kazuhiro Omura1, Kosuke Terazawa2, Kazuhiro Nomura3
1Department of Otolaryngology, The Jikei University School of Medicine, Tokyo, Japan.
Background:
Olfactory neuroblastoma (ONB) is a rare malignant tumor originating from the nasal olfactory sensory epithelium. It accounts for 3%-5% of all sinonasal malignancies.
Methods:
We evaluated patients with ONB who underwent en bloc resection using an endoscopic endonasal transcribriform approach.
Results:
This study included 65 patients. The median follow-up period was 30.6 months. The 2- and 5-year overall survival (OS) rates were both 96.7%, the 2- and 5-year disease-specific survival (DSS) rates were both 98.3%, and the 2- and 5-year disease-free survival (DFS) rates were 81.7% and 59.1%, respectively.
Conclusion:
OS and DFS of en bloc resection were comparable to those reported in previous studies, with minimal operation-related complications. Recurrence can occur even in patients with low Kadish and Hyams grades, making it unclear which patients would benefit most from postoperative radiation therapy.
