Related Experiment Video
Updated: Apr 10, 2026
Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
Published on: April 3, 2026
Extended Transoral Resection of Anterior Commissure Tumors in a Canine Model: Impact on Laryngeal Framework, Glottis,
Zhongyi Wu1, Li Wang2, Yuheng Lu1
1Department of Otolaryngology-Head and Neck Surgery The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi People's Republic of China.
Background And Objectives:
Evaluate the feasibility and functional outcomes of extended transoral resection for anterior commissure (AC) tumors in canines, focusing on laryngeal framework, airway, and vocal function.
Methods:
Twelve dogs underwent endoscopic partial thyroid cartilage resection, randomized into: Group A (AC + adjacent cartilage), Group B (AC + left vocal cord anterior 1/3), Group C (AC + bilateral vocal cord anterior 1/3). Outcomes assessed included laryngoscopic healing, CT-measured laminal angle (LA) and glottal area (GA), weight, and GRBAS vocal scores.
Results:
The wound healed and epithelized in 4 weeks. Postoperative LA significantly decreased in all groups (p ≤ 0.010), with the largest reduction in Group C (p ≤ 0.030 vs. A/B). LA reduction ratio correlated with resected midline height (RMH) (r = 0.546, p = 0.041) rather than resection factors of width and area. GA remained stable. Group C showed severe vocal impairment (GRBAS 8.67 ± 0.58 vs. 5.63 ± 0.48 in A, p = 0.008). Weight transiently decreased at day 7 but recovered by day 35.
Conclusion:
Extended transoral resection effectively removes AC lesions while preserving airway dimensions. However, extensive resection causes significant vocal dysfunction, highlighting the balance between oncologic radicality and function preservation. The potential LA-RMH correlation reveals the stabilizing characteristics of cartilaginous structures, offering preclinical insights for optimizing AC cancer surgery.
