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The potential hematological features of children with spastic cerebral palsy in China: a retrospective
Yanjun Mo1,2, Yu Jiang1, Zhaozhan Qiang3
1Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Insights
Routine blood markers like alkaline phosphatase and creatinine are associated with spastic cerebral palsy (SCP) risk. These findings aid in monitoring SCP patients and optimizing treatment strategies.
Area of Science:
- Pediatrics
- Neurology
- Hematology
Background:
- Spastic cerebral palsy (SCP) is a common neurological disorder affecting posture and movement.
- Previous studies indicated differences in inflammatory markers between SCP patients and controls.
- This research expands on prior findings with a larger sample size.
Purpose of the Study:
- To identify hematological features of spastic cerebral palsy (SCP) using routine blood tests.
- To analyze multidimensional data from hematological indicators in SCP.
- To provide potential new directions for SCP treatment.
Main Methods:
- Retrospective study of 305 children with SCP and 149 healthy children (aged 3-12 years).
- Collected and analyzed routine blood and biochemical test results.
- Performed statistical analysis, including logistic regression and subgroup analysis by age.
Main Results:
- SCP patients showed significantly lower alkaline phosphatase (ALP), creatinine (Cr), SII, and MPV/PC levels compared to controls.
- SCP patients had significantly higher AST/ALT and NLR levels.
- Logistic regression identified ALP, Cr, SII, and MPV/PC as protective factors, while AST/ALT and NLR were risk factors for SCP.
Conclusions:
- Routine hematological indicators like ALP, Cr, AST/ALT, SII, MPV/PC, and NLR are significantly associated with SCP risk.
- These findings offer valuable references for clinicians in monitoring SCP patients.
- The results can aid in optimizing treatment plans and nutritional interventions for children with cerebral palsy.
Background:
Cerebral palsy (CP) is a non-progressive brain injury primarily characterized by abnormal posture and movement disorders. Among them, spastic cerebral palsy (SCP) accounts for 70% of cases. Previous small sample hematological data analyses have revealed significant differences in inflammatory marker ratios between SCP patients and healthy controls. This study aims to expand the sample size and perform a multidimensional data analysis using routine hematological indicators to identify hematological features of spastic cerebral palsy, potentially providing new directions for the treatment of SCP.
Methods:
This retrospective study included 305 children with spastic cerebral palsy and 149 healthy children, aged 3-12 years. Previous routine blood and biochemical test results were collected from the participants. Statistical analysis was performed on clinically common indicators and related composite indicators, and subgroup analyses were conducted based on age group (preschool vs. school-age).
Results:
Compared to the healthy control group, SCP patients had significantly lower levels of NPAR, alkaline phosphatase (ALP), creatinine (Cr), SII, and MPV/PC (p < 0.05). AST/ALT, NLR, total protein, and SIRI levels were significantly higher in the SCP group (p < 0.05). Logistic regression analysis showed that ALP, Cr, SII, and MPV/PC were protective factors for SCP, while AST/ALT and NLR were risk factors for SCP. Combining these indicators for SCP diagnosis, the ROC curve analysis yielded an AUC of 0.781. Subgroup analysis showed that children aged 3-6 years with SCP had significantly lower Cr, AST/ALT, SII, MPV/PC, and NLR levels compared to children aged 7-12 years with SCP. Furthermore, creatinine, AST/ALT, SII, MPV/PC, and NLR levels were positively correlated with the age of SCP children.
Conclusion:
This study reveals a significant association between alkaline phosphatase, creatinine, AST/ALT, SII, MPV/PC, NLR in routine blood indicators and the risk of SCP, providing important reference for clinicians to monitor the health status of children with cerebral palsy, optimize treatment plans, and implement nutritional interventions.
