Related Experiment Video
Updated: Apr 10, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
1-Ethenyl-2-(methyl-sulfan-yl)-4,4-diphenyl-4,5-di-hydro-1H-imidazol-5-one (Thio-phenytoin analogue): synthesis,
Abderrazzak El Moutaouakil Ala Allah1, Chiara Massera2, Joel T Mague3
1Laboratory of Medicinal Chemistry Drug Sciences Research Center Faculty of Medicine and Pharmacy Mohammed V University in Rabat Morocco.
Abstract:
The title mol-ecule, C18H16N2OS, exhibits a slight 'ruffling' of the imidazolone ring, and the lone pair on the tricoordinate nitro-gen atom is involved in N→C π-bonding within the ring. Both the methyl group bonded to sulfur and the vinyl substituent lie very close to the plane of the five-membered ring. In the crystal, C-H⋯O hydrogen bonds form inversion dimers, which are linked into chains extending along the b-axis direction by C-H⋯π(ring) inter-actions. Hirshfeld surface analysis indicates that H⋯H inter-actions account for more than half of the inter-molecular contacts, with C-H⋯π(ring) inter-actions contributing a further quarter of the total.
More Related Videos
10:42Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
09:54Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Related Concept Videos
Structure and Nomenclature of Thiols and Sulfides
Newman Projections
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
Fischer Projections
Preparation and Reactions of Sulfides
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Structures of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...