Related Experiment Video
Updated: Apr 10, 2026

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
Published on: May 13, 2012
Dynamics of a two-patch epidemic model with deterministic/stochastic migration and distributed delays
Ting Kang1,2, Boqiang Cao1,2, Zhenfeng Shi3
1School of Mathematics and Statistics, Ningxia University, Yinchuan, 750021, China.
Abstract:
We study the global dynamics of a two-patch epidemic model that integrates spatial migration, Erlang-distributed delays, and environmental stochasticity. The two patches are coupled by migration whose intensities are modulated by an Ornstein-Uhlenbeck (OU) process, capturing stochasticity but mean-reverting fluctuations in population movement, while the infection progression is described by a distributed delay structure represented through a linear-chain formulation. For the deterministic system, we establish threshold-type results that characterize disease extinction and persistence: the disease-free equilibrium is globally asymptotically stable when the basic reproduction number , whereas infection persists when . For the corresponding stochastic model, we derive explicit sufficient conditions for almost sure exponential extinction by constructing Lyapunov functions and exploiting the Metzler structure of the infected subsystem. Moreover, we prove that the stochastic system admits a stationary distribution when stochastic threshold , which serves as a stochastic analogue of the endemic equilibrium and describes persistent random fluctuations of infection levels. Numerical simulations are provided to validate the theoretical findings and to quantify how distributed delays and OU-driven migration randomness shape long-term infection burden and stationary prevalence across patches. Notably, adjusting the noise intensity and the mean-reversion rate can redistribute the long-term infection burden between patches, which highlights how migration-driven randomness fundamentally reshapes spatial epidemic patterns.
Related Concept Videos
Modeling with Differential Equations
Population Growth
Pharmacodynamic Models: Link Model and Systems Pharmacodynamic Model
Pharmacokinetic–Pharmacodynamic Relationship: Model Components
Exponential Equations for Modeling Growth
Poisson's And Laplace's Equation

