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Sex differences in LMR ratio and coronary artery stenosis severity among patients with coronary artery disease
Cheng Cao1, Wenyi Pang1, Lingling Lu1
1Cardiology Department, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei, Cangzhou, Hebei, China.
Insights
The lymphocyte-to-monocyte ratio (LMR) is linked to coronary artery disease (CAD) severity. This inflammatory marker is inversely associated with CAD severity, showing a stronger connection in women.
Area of Science:
- Cardiovascular Medicine
- Inflammation Biomarkers
- Hematology
Background:
- The lymphocyte-to-monocyte ratio (LMR) is a potential indicator of inflammation.
- Previous research suggests LMR correlates with coronary artery disease (CAD) severity.
- Sex-based differences in the LMR-CAD severity association are not well-established.
Purpose of the Study:
- To investigate the association between LMR and CAD severity, quantified by the Gensini score.
- To determine if this association differs between male and female patients.
Main Methods:
- Analysis of 1,673 patients undergoing coronary angiography.
- CAD severity assessed using the Gensini score and categorized into tertiles.
- Sex-stratified analyses and multivariable regression models were used.
Main Results:
- LMR was significantly lower in patients with higher Gensini scores (P < 0.001).
- LMR showed an independent inverse association with Gensini score in the overall cohort.
- A significant sex-LMR interaction (P < 0.05) indicated a stronger inverse association in females.
Conclusions:
- LMR is an independent inverse predictor of CAD severity.
- The association between LMR and CAD severity is stronger in women than in men.
- LMR may serve as a sex-specific inflammatory marker for CAD assessment.
Background:
Previous studies have indicated that the lymphocyte-to-monocyte ratio (LMR) is associated with the severity of coronary artery disease (CAD). However, whether this association differs between sexes remains unclear. This study aimed to evaluate the association between LMR and Gensini score in patients with CAD, with a focus on potential sex differences.
Methods:
A total of 1,673 patients undergoing coronary angiography were included. The severity of CAD was assessed using the Gensini score, and patients were categorized into three groups based on Gensini score tertiles: T1 (≤10), T2 (>10 to <44), and T3 (≥44). Sex-stratified analyses and multivariable regression models were employed to assess the association between LMR and CAD severity.
Results:
LMR was significantly lower in patients with higher Gensini scores (P < 0.001). After multivariable adjustment, LMR was independently and inversely associated with the Gensini score in the overall population. A significant sex-LMR interaction was observed (P < 0.05). In sex-stratified analyses, the inverse association between LMR and Gensini score was stronger in females than in males.
Conclusion:
LMR is independently and inversely associated with the severity of CAD, with a stronger association observed in female patients. These findings suggest that LMR may serve as a potential inflammatory marker for assessing CAD severity, and its clinical relevance may differ between sexes.
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