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Updated: Apr 10, 2026

Author Spotlight: Optimizing Bovine Lung Decellularization for Organotypic Hydrogels

Author Spotlight: Optimizing Bovine Lung Decellularization for Organotypic Hydrogels

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Thermoreversible cell-derived extracellular matrix only hydrogel (CEOgel): Development, characterization, and

Byoungha An^1,2, Jae Won Kwon¹, Heejeong Yoon³

¹Center for Biomaterials, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

Materials Today. Bio

|April 9, 2026

Summary

Researchers developed CEOgel, a novel thermoreversible hydrogel made entirely from cell-derived extracellular matrix (cECM). This biomaterial supports cell growth and tissue regeneration without animal products or external cross-linkers.

Keywords:

Cell-derived extracellular matrix Decellularized extracellular matrix ECM hydrogel Thermoreversible Thermosensitive

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Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

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Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Published on: December 4, 2017

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Decellularized extracellular matrix (dECM) is crucial for 3D cell culture and tissue regeneration.
Cell-derived ECM (cECM) offers an alternative to tissue-derived dECM, but thermosensitive hydrogels are underexplored.
Existing cECM formulations lack thermoreversible properties.

Purpose of the Study:

To develop a novel thermoreversible hydrogel exclusively from cell-derived extracellular matrix (cECM).
To characterize the properties and potential applications of this new biomaterial, termed CEOgel.
To explore tunable properties and expand the design diversity of ECM hydrogels.

Main Methods:

Decellularization of in vitro-cultured umbilical cord mesenchymal stem cells to enhance cECM solubility.
Concentration of cECM nanofibers to create CEOgel without additional factors.
Characterization of CEOgel's mechanical stability, thermosensitivity, biocompatibility, and protein composition via proteomics.

Main Results:

CEOgel is a thermoreversible hydrogel formed solely from cECM, applicable across multiple cell types with minimal variability.
The hydrogel demonstrates mechanical stability for in vitro use and in vivo gelation, confirming thermosensitivity and biocompatibility.
CEOgel supports endothelial vascularization and cancer organoid growth, containing a broad spectrum of human tissue proteins.

Conclusions:

CEOgel represents a new class of thermoreversible cECM hydrogels, eliminating the need for animal tissues or external cross-linkers.
This biomaterial expands the utility of cECM and advances ECM hydrogel design for regenerative medicine.
CEOgel shows significant potential as a regenerative biomaterial for tissue engineering and various medical applications.