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Cardiac Action Potential

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

Compartment Models: Single-Compartment Model

Compartment Models: Single-Compartment Model

The single-compartment model serves as a simplified representation of the human body. This model assumes that the body functions as a single, well-mixed open compartment. When a drug is administered intravenously, it enters the body and quickly distributes uniformly. The drug then undergoes biotransformation and elimination, ultimately leaving the body. The volume of this compartment is referred to as the apparent volume of distribution into which the drug can uniformly distribute. In this...

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Related Experiment Video

Updated: Apr 10, 2026

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

Published on: January 8, 2013

Fast Parameterization of Human Ventricular Ionic Models Using CardioFit.

Maxfield R Comstock¹, Flavio H Fenton², Elizabeth M Cherry¹

¹School of Computational Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

Computing in Cardiology

|April 9, 2026

Summary

This summary is machine-generated.

CardioFit is a new web tool that uses particle swarm optimization (PSO) to quickly tune cardiac action potential (AP) model parameters. It efficiently matches detailed ionic models to experimental data in minutes.

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Last Updated: Apr 10, 2026

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

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Published on: January 8, 2013

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

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Published on: February 13, 2021

Area of Science:

Computational biology
Cardiac electrophysiology
Biophysics

Background:

Cardiac action potential (AP) models require accurate parameterization for reliable simulation.
Tuning these parameters to match experimental data is often challenging and time-consuming.

Purpose of the Study:

To develop an efficient computational tool, CardioFit, for fitting cardiac AP model parameters.
To facilitate the optimization of detailed human ventricular models using experimental time-series data.

Main Methods:

CardioFit employs particle swarm optimization (PSO) for parameter fitting.
The tool is a web-based application utilizing JavaScript and WebGL for GPU acceleration.
Parallel processing capabilities of PSO are leveraged for rapid computation.

Main Results:

CardioFit rapidly identifies conductance parameter values for detailed ionic models (e.g., ten Tusscher et al., O'Hara et al.).
The tool successfully matches model outputs to experimental data within model limitations.
Parameter fitting is achieved in minutes on consumer hardware, despite requiring thousands of model runs.

Conclusions:

CardioFit offers a fast and accessible solution for optimizing cardiac electrophysiology models.
The web-based, GPU-accelerated approach significantly reduces the time needed for model parameterization.
This tool aids researchers in achieving better fits of ionic models to experimental AP data.