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PCPE1 and PCPE2: When Sequence Similarity Masks Functional Diversity.

Mary G Sorci-Thomas1,2,3, Alexander Rocksvold2,3, Bilal Ahmad1,2

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Summary

Procollagen C-endopeptidase enhancers (PCPE) 1 and PCPE2 are extracellular matrix glycoproteins with overlapping and distinct roles. Beyond collagen processing, they regulate key biological functions like immune response and tissue remodeling.

Keywords:
atherosclerosiscoronary vesselsmembrane proteinspathologiststissue distribution

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Procollagen C-endopeptidase enhancers (PCPE) 1 and PCPE2 are extracellular matrix (ECM) glycoproteins.
  • They regulate procollagen processing and collagen maturation.
  • Initially, PCPE1 and PCPE2 were thought to have similar functions due to structural similarities.

Purpose of the Study:

  • To investigate the distinct and overlapping biological functions of PCPE1 and PCPE2.
  • To explore their roles beyond traditional ECM remodeling and collagen processing.

Main Methods:

  • Comparative analysis of PCPE1 and PCPE2 functions.
  • Review of recent evidence on their involvement in various biological processes.

Main Results:

  • PCPE1 is involved in adipose-to-liver crosstalk, angiogenesis, and fibrosis/wound healing.
  • PCPE2 inhibits PCPE1's procollagen processing enhancement and participates in cellular plasticity, innate immunity, and adipose tissue expansion.
  • PCPE1 and PCPE2 share functional overlap but also exhibit unique regulatory roles.

Conclusions:

  • PCPE1 and PCPE2 possess both shared and distinct biological functions.
  • These glycoproteins play significant regulatory roles extending beyond ECM remodeling.