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IoT-Based Home Blood Pressure Time in Target Range and Brain Lesions on MRI
Takashi Hisamatsu1, Mari Fukuda1, Minako Kinuta1,2
1Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan (T.H., M.F., M.K., N.N., H.K.).
Hypertension (Dallas, Tex. : 1979)
|April 9, 2026
Summary
Higher time in target range (TTR) for home blood pressure (BP) is linked to fewer brain lesions. This finding highlights TTR
Area of Science:
- Cardiovascular Research
- Neurology
- Medical Technology
Background:
- Time in Target Range (TTR) quantifies blood pressure (BP) control within recommended levels.
- Distribution and clinical significance of home BP TTR, especially concerning subclinical cerebrovascular disease, remain under-explored in community settings.
Purpose of the Study:
- To evaluate annual and seasonal TTR using Internet of Things (IoT)-based home BP monitoring.
- To investigate the association between home BP TTR and subclinical cerebrovascular disease detected via MRI in a community-based cohort.
Main Methods:
- Home BP was monitored twice daily, with weekly means derived from at least three daily readings.
- TTR was calculated as the percentage of weeks meeting specific BP targets (<135/85 mmHg for untreated, <125/75 mmHg for treated individuals).
- Brain lesions (lacunar infarcts, white matter hyperintensities, microbleeds, intracranial stenosis) were assessed using MRI.
Main Results:
- Median annual TTR was 100% for untreated and 1.9% for treated participants.
- TTR was generally lower in winter compared to summer.
- Higher TTR correlated with a reduced prevalence of brain lesions (PR per 10% increase: 0.85; 95% CI, 0.79-0.91), with a stronger association in untreated individuals.
Conclusions:
- Home BP TTR offers valuable insights into long-term BP management.
- TTR assessment can provide complementary information for evaluating cerebrovascular health.
