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Updated: Apr 10, 2026
Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood
Published on: February 5, 2020
When Binding Is Not Blockade: Interpreting IgG4+ T Cells After PD-1 Therapy
Man Sun1, Dan Zang1, Jun Chen1
1Department of Oncology, The Second Hospital of Dalian Medical University, Dalian City, Liaoning Province, China.
IgG4 positivity on circulating T cells after PD-1 therapy may indicate residual antibody binding rather than sustained functional PD-1 blockade. During sequential ramucirumab plus docetaxel plus G-CSF treatment, peripheral IgG4+ T-cell dynamics may also be influenced by redistribution and treatment-related confounders, limiting direct inference about effective intratumoral antitumor immunity.
IgG4 positivity on circulating T cells after PD-1 therapy may indicate residual antibody binding rather than sustained functional PD-1 blockade. During sequential ramucirumab plus docetaxel plus G-CSF treatment, peripheral IgG4+ T-cell dynamics may also be influenced by redistribution and treatment-related confounders, limiting direct inference about effective intratumoral antitumor immunity.
