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Urinary Collagen Peptides Predict Mortality.

Maria Frantzi1, Felix Keller2, Agnieszka Latosinska1

  • 1Department of Biomarker Research, Mosaiques Diagnostics GmbH, Hannover, Germany.

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Summary
This summary is machine-generated.

Urinary collagen peptides, fragments of extracellular matrix (ECM), can predict mortality in critically ill and non-critically ill patients. This non-invasive biomarker may guide future interventions for fibrosis-related mortality.

Keywords:
collagenextracellular matrixfibrosismass spectrometrymortalityurinary peptides

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Area of Science:

  • Biomarkers
  • Proteomics
  • Organ Fibrosis

Background:

  • Organ fibrosis, driven by excessive extracellular matrix (ECM), is linked to mortality.
  • Urinary peptide signatures, largely collagen fragments, predict mortality in SARS-CoV-2 and chronic kidney disease.

Purpose of the Study:

  • To investigate if urinary collagen peptides, indicative of organ fibrosis, can predict mortality in critical and non-critical patient conditions.

Main Methods:

  • Analyzed urinary proteomic data from 1012 patients (CRIT-COV-U study) for collagen peptide association with short-term mortality.
  • Validated findings in independent datasets of 9193 patients (ICU and non-ICU).
  • Developed and validated a collagen peptide classifier (COL210) for mortality prediction.

Main Results:

  • 607 collagen peptides significantly associated with mortality.
  • The COL210 classifier demonstrated strong mortality prediction in ICU (HR: 2.64) and non-ICU (HR: 2.16) patients.
  • Mortality prediction was consistent across diverse underlying conditions.

Conclusions:

  • Urinary collagen fragments are linked to increased mortality risk.
  • A non-invasive, collagen-based urinary biomarker can predict mortality.
  • This finding may facilitate proteomics-guided interventions for fibrosis.