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Updated: Apr 10, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
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Therapeutic hypothermia for newborns with hypoxic-ischaemic encephalopathy

Anne Fink1,2, Marie T Berg3, Roger F Soll4,5

  • 1Department of Child and Adolescent Psychiatry, Neurology, Psychosomatics, and Psychotherapy, University Medical Center Rostock, Rostock, Germany.

The Cochrane Database of Systematic Reviews
|April 9, 2026
PubMed

Insights

Therapeutic hypothermia (TH) may benefit newborns with hypoxic-ischaemic encephalopathy (HIE). This review evaluates TH versus standard care to determine its safety and effectiveness in infants.

Area of Science:

  • Neonatal medicine
  • Neurology
  • Pediatrics

Background:

  • Hypoxic-ischaemic encephalopathy (HIE) is a serious birth complication.
  • Standard care for HIE has limited efficacy.
  • Therapeutic hypothermia (TH) is a potential neuroprotective strategy.

Purpose of the Study:

  • To assess the benefits and harms of TH in newborns with HIE.
  • To compare TH with standard care for HIE treatment.
  • To inform clinical practice guidelines for HIE management.

Main Methods:

  • This is a protocol for a Cochrane Review.
  • The review will synthesize evidence from randomized controlled trials.
  • Data on mortality, neurological outcomes, and adverse events will be analyzed.

Main Results:

  • Evidence synthesis is ongoing.
  • Anticipated results will guide therapeutic decisions.
  • The review aims to provide a comprehensive assessment of TH efficacy.

Conclusions:

  • The findings will clarify the role of TH in HIE.
  • This review will support evidence-based neonatal care.
  • Optimizing HIE management is crucial for infant outcomes.
Abstract

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