Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

2.8K
In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
2.8K
Light Acquisition02:16

Light Acquisition

9.9K
In order to produce glucose, plants need to capture sufficient light energy. Many modern plants have evolved leaves specialized for light acquisition. Leaves can be only millimeters in width or tens of meters wide, depending on the environment. Due to competition for sunlight, evolution has driven the evolution of increasingly larger leaves and taller plants, to avoid shading by their neighbors with contaminant elaboration of root architecture and mechanisms to transport water and nutrients.
9.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Large neutral amino acid uptake and mTOR activation within CD4 T cells coordinate type 2 immunity and host resistance to <i>Trichuris muris</i>.

Discovery immunology·2026
Same author

The gut microbiome and metabolome associate with Schistosoma mansoni infection and cardiovascular disease risk in Uganda.

Nature communications·2026
Same author

New Perspectives on Classical Alarmin Responses to Intestinal Helminth Infection.

Parasite immunology·2025
Same author

Brain sensing of metabolic state regulates circulating monocytes.

Science immunology·2025
Same author

Gut GABA keeps ILC3s in check.

Nature immunology·2025
Same author

An optimised faecal microRNA sequencing pipeline reveals fibrosis in Trichuris muris infection.

Nature communications·2025

Related Experiment Video

Updated: Apr 10, 2026

Author Spotlight: A Novel Standardized Technique for Real-Time Biomedical Imaging of Acute Myocardial Injury
07:17

Author Spotlight: A Novel Standardized Technique for Real-Time Biomedical Imaging of Acute Myocardial Injury

Published on: March 22, 2024

1.8K

ILC2s ride the Blimp to fly.

Matthew R Hepworth1,2, Richard K Grencis1,2

  • 1School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester , Manchester, UK.

The Journal of Experimental Medicine
|April 9, 2026
PubMed
Summary

This study identifies the transcription factor Blimp-1 as crucial for optimal effector cytokine secretion in innate lymphoid cells (ILC2s). Blimp-1 controls type 2 immunity by regulating cytokine release in ILC2 cells.

More Related Videos

Simultaneous Measurement of Turbulence and Particle Kinematics Using Flow Imaging Techniques
10:53

Simultaneous Measurement of Turbulence and Particle Kinematics Using Flow Imaging Techniques

Published on: March 12, 2019

7.7K
Direct Imaging of Laser-driven Ultrafast Molecular Rotation
10:52

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Published on: February 4, 2017

10.3K

Related Experiment Videos

Last Updated: Apr 10, 2026

Author Spotlight: A Novel Standardized Technique for Real-Time Biomedical Imaging of Acute Myocardial Injury
07:17

Author Spotlight: A Novel Standardized Technique for Real-Time Biomedical Imaging of Acute Myocardial Injury

Published on: March 22, 2024

1.8K
Simultaneous Measurement of Turbulence and Particle Kinematics Using Flow Imaging Techniques
10:53

Simultaneous Measurement of Turbulence and Particle Kinematics Using Flow Imaging Techniques

Published on: March 12, 2019

7.7K
Direct Imaging of Laser-driven Ultrafast Molecular Rotation
10:52

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Published on: February 4, 2017

10.3K

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Innate lymphoid cells (ILCs) are key players in immune responses.
  • Type 2 immunity involves complex cellular signaling pathways.
  • Cytokine secretion by ILC2s is critical for mediating type 2 immune responses.

Purpose of the Study:

  • To investigate the role of transcription factors in regulating ILC2 function.
  • To identify key regulators of effector cytokine secretion in type 2 immunity.
  • To elucidate the mechanism by which alarmin signaling impacts ILC2 effector functions.

Main Methods:

  • The study likely involved in vitro assays using ILC2 cells.
  • Investigated the expression and function of Blimp-1 in ILC2s.
  • Analyzed cytokine production following alarmin stimulation.

Main Results:

  • Blimp-1 was identified as a pivotal transcription factor in ILC2 cells.
  • Blimp-1 is critical for optimal effector cytokine secretion.
  • Alarmin activation of ILC2s is dependent on Blimp-1 function.

Conclusions:

  • Blimp-1 is an alarmin-activated transcription factor essential for type 2 immunity.
  • Blimp-1 controls optimal effector cytokine secretion in ILC2s.
  • This finding advances understanding of ILC2 regulation in immune responses.