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Derivation of Leptomeninges Explant Cultures from Postmortem Human Brain Donors
Published on: January 21, 2017
Three donor-matched iPSC lines derived from human postmortem dura mater for modeling neurodegenerative diseases
Yu-Mi Shim1, Sooyeon Yoo1, Hyung-Jin Kwon2
1Department of Pathology, Seoul National University Hospital, Seoul, the Republic of Korea; Brain Bank, Seoul National University Hospital, Seoul, the Republic of Korea.
Abstract:
We generated three donor-matched induced pluripotent stem cell (iPSC) lines from postmortem dura-derived fibroblasts obtained from donors with neuropathologically confirmed Alzheimer's disease (AD), Parkinson's disease (PD), and primary age-related tauopathy (PART) with TDP-43 co-pathology. All lines exhibited characteristic features of the undifferentiated human pluripotent stem cell (hPSC) state and maintained donor-specific genomic identity with stable variant profiles. These well-characterized iPSC lines provide valuable resources for modeling neurodegenerative diseases and for generating isogenic neural derivatives comparable to autopsy brain tissues from the same individuals.

