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The causal relationship between sarcopenia traits and abdominal hernia: A bidirectional Mendelian randomization study
Dazhou Wu1, Xiuman Chen2, Dongdong Huang1
1Department of Hernia and abdominal wall surgery, The First Affiliated Hospital of Wenzhou Medical University, PR China.
Experimental Gerontology
|April 9, 2026
Summary
Sarcopenia traits like walking pace and muscle mass may protect against abdominal hernia (AH). Conversely, AH might negatively impact these sarcopenia markers, suggesting a bidirectional relationship.
Area of Science:
- Genetics
- Epidemiology
- Gerontology
Background:
- Sarcopenia is a potential risk factor for abdominal hernia (AH) post-surgery.
- The causal link between sarcopenia and AH requires further investigation.
Purpose of the Study:
- To explore the bidirectional causal relationship between sarcopenia and AH using Mendelian randomization (MR).
Main Methods:
- Utilized bidirectional MR analysis with single-nucleotide polymorphisms (SNPs) as instrumental variables.
- Employed MR-Egger regression and inverse-variance weighted (IVW) methods.
- Assessed SNP heterogeneity, pleiotropy, and performed sensitivity analyses.
Main Results:
- A mutual causal relationship was observed between sarcopenia traits and AH occurrence.
- Sarcopenia traits (walking pace, appendicular lean mass, hand grip strength) showed a protective effect against AH.
- AH also demonstrated a protective effect on sarcopenia traits, indicating a bidirectional influence.
Conclusions:
- Improving sarcopenia markers (walking pace, lean mass, grip strength) may reduce AH risk.
- Aggravated AH could potentially lead to declines in physical function and muscle mass.
