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Imaging Studies for Cardiovascular System I:Echocardiography

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...

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Updated: Apr 11, 2026

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Cardiac Multifrequency Time-harmonic Elastography: In Silico Validation and In Vivo Application.

Stefan Klemmer Chandía¹, Brunhilde Wellge^2,3, Gina Barzen^3,4

¹Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Radiology, Germany, Berlin.

Ultraschall in Der Medizin (Stuttgart, Germany : 1980)

|April 9, 2026

Summary

This summary is machine-generated.

Optimized cardiac time-harmonic elastography (THE) accurately detects abnormal diastolic stiffness in transthyretin amyloidosis (ATTRwt) patients. This portable ultrasound method offers a rapid, low-cost approach for diagnosing cardiomyopathies.

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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

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Last Updated: Apr 11, 2026

In Silico Clinical Trials for Cardiovascular Disease

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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

Area of Science:

Cardiovascular Imaging
Medical Ultrasound
Biomedical Engineering

Background:

Myocardial stiffness, particularly diastolic stiffness, is a key indicator of cardiac dysfunction.
Transthyretin amyloidosis (ATTRwt) is a progressive disease characterized by abnormal myocardial stiffening.
Accurate, non-invasive methods are needed to assess myocardial stiffness and diagnose conditions like ATTRwt.

Purpose of the Study:

To introduce and validate an optimized multifrequency cardiac time-harmonic elastography (THE) technique.
To assess THE's ability to detect abnormal diastolic stiffness using portable drivers and multi-heartbeat acquisitions.
To investigate THE's diagnostic performance in patients with cardiac wild-type transthyretin amyloidosis (ATTRwt) compared to healthy controls.

Main Methods:

Cardiac THE was performed using a portable driver inducing continuous vibrations at 60, 70, and 80 Hz.
Shear wave speed (SWS) maps, a proxy for myocardial stiffness, were acquired over 4 seconds.
In silico simulations using CT-data-based anatomies validated the technique and optimized parameters. Diagnostic performance was assessed using ROC analysis.

Main Results:

The study included 10 healthy controls and 11 patients with ATTRwt.
Cardiac THE accurately detected ATTRwt with an AUC of 1.00 (95% CI: 0.94-1.00).
In silico SWS estimations showed strong agreement with ground truth (r²=0.94) across various stiffnesses and thicknesses.

Conclusions:

Cardiac THE accuracy was quantified for the first time in silico and in vivo, including an ATTRwt cohort.
Multifrequency shear waves from portable drivers, encoded in standard ultrasound, offer rapid, low-cost contrast.
This technique aids in detecting cardiomyopathies such as amyloidosis by assessing myocardial stiffness.