Enhanced adenoma detection with Endocuff Vision: a GRADE assessed systematic review and meta-analysis

Area of Science:

• Gastroenterology
• Oncology
• Medical Devices

Background:

• Colorectal cancer (CRC) is a leading cause of cancer mortality globally.
• Early detection of adenomas via colonoscopy is crucial for reducing CRC incidence and mortality.
• Higher adenoma detection rates (ADRs) correlate with improved patient outcomes.

Purpose of the Study:

• To evaluate the efficacy of Endocuff Vision (EV) in improving adenoma detection rates (ADRs) during colonoscopy.
• To compare polyp detection rates (PDRs) and adverse events (AEs) between EV-assisted and standard colonoscopy.
• To synthesize evidence from multiple studies through a systematic review and meta-analysis.

Main Methods:

• Systematic review and meta-analysis adhering to PRISMA guidelines.
• Searched PubMed, Embase, and Cochrane databases up to April 2025.
• Pooled data from 34 studies involving 43,702 participants using random-effects models.

Main Results:

• EV significantly increased ADRs (RR 1.15) and PDRs (RR 1.16).
• Enhanced lesion detection was observed in both the left (RR 1.23) and right (RR 1.19) colon.
• No significant improvement in advanced ADRs or cecal intubation; increased AEs were noted with EV.

Conclusions:

• EV-assisted colonoscopy improves adenoma and polyp detection, thereby enhancing colorectal cancer screening.
• The benefits of improved detection with EV must be weighed against the increased risk of adverse events.
• Further research may explore strategies to mitigate AEs while maximizing EV's detection benefits.