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Direct Bioprinting of 3D Multicellular Breast Spheroids onto Endothelial Networks

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Using biomaterial-based 3D in vitro cancer models to solve current clinical problems.

Eve Tipple^1,2, Ellen Slay^2,3, Olga Tsigkou^1,2

¹Department of Materials, Faculty of Science & Engineering, School of Natural Sciences, University of Manchester, Manchester, UK.

British Journal of Cancer

|April 9, 2026

Summary

This summary is machine-generated.

Biomaterial-based 3D models offer advanced cancer research tools. These innovative in vitro models mimic the tumor microenvironment, improving drug screening and treatment studies while overcoming limitations of current preclinical methods.

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Area of Science:

Biomaterials Science
Cancer Biology
Preclinical Research

Background:

Cancer progression involves complex cellular and acellular interactions.
Current preclinical models (2D cultures, animal models) have significant limitations, including cost, time, and accuracy.
Biomaterials can create advanced 3D in vitro models that better recapitulate the tumor microenvironment.

Purpose of the Study:

To review the role of biomaterial-based 3D in vitro models in cancer research.
To highlight how these models address limitations of existing preclinical approaches.
To bridge the gap between current research and potential clinical impact.

Main Methods:

Utilizing tuneable, biocompatible materials like hydrogels as scaffolds.
Seeding cancer cells and other components to mimic tumor extracellular matrix.
Developing 3D in vitro models that replicate key aspects of the tumor microenvironment.

Main Results:

Biomaterial-based 3D models effectively mimic the tumor microenvironment.
These models show promise for drug screening and investigating treatment responses.
Demonstrated capability to model cancer progression mechanisms.

Conclusions:

Biomaterial-based 3D in vitro models represent a significant advancement in cancer research.
These models offer a more accurate and efficient platform compared to traditional methods.
Potential to accelerate the development of novel cancer treatments and improve clinical outcomes.