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Group-Based Medical Mistrust and Logistical Factors Influencing Rheumatology Clinical Trial Enrollment: A
Andreina Martinez Paulino1, Danny Jose Arias Diaz1, Miles King2
1Rutgers University and Robert Wood Johnson Barnabas Health, Jersey City, New Jersey.
ACR Open Rheumatology
|April 9, 2026
Summary
Group-based medical mistrust did not affect rheumatology clinical trial enrollment willingness. Instead, patients prioritized potential disease improvement and physician encouragement for participation.
Area of Science:
- Rheumatology
- Clinical Trials
- Health Disparities
Background:
- Medical mistrust, particularly group-based mistrust, can influence healthcare decisions.
- Understanding factors affecting clinical trial enrollment is crucial for advancing rheumatology research.
Purpose of the Study:
- To determine if group-based medical mistrust predicts willingness to enroll in rheumatology clinical trials.
- To identify key logistical factors influencing decisions for patients unwilling to participate.
Main Methods:
- A cross-sectional survey was conducted at an academic rheumatology clinic.
- Participants completed the Group-Based Medical Mistrust Scale (GBMMS) and rated logistical factors.
- Statistical analyses included Welch's t-test and univariable logistic regression.
Main Results:
- Group-based medical mistrust did not significantly predict willingness to enroll in a clinical trial.
- Patients unwilling to participate cited disease progression, physician encouragement, and logistics as primary concerns.
- Willingness to enroll was not associated with GBMMS scores.
Conclusions:
- Group-based medical mistrust is not a significant barrier to rheumatology clinical trial enrollment.
- Potential for disease improvement and physician endorsement are key drivers of participation.
- Recruitment strategies should focus on realistic benefits, physician involvement, and logistical support.
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