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Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise
Published on: February 20, 2017
Determinants of Improved Dyspnea and Exercise Tolerance With Nasal High-Flow O2 Therapy in Fibrotic Interstitial Lung
Sarah Thivent1,2, Marylise Ginoux1, Samuel Verges2
1Cardiopulmonary Rehabilitation Centre Dieulefit Santé, Dieulefit, France.
Abstract:
We tested the respective effect of high-flow and supplemental O2 from nasal high-flow O2 therapy (NHFO2) on dyspnea and exercise tolerance in fibrotic interstitial lung disease. Supplemental O2 and NHFO2 (but not high-flow) provided improvements in these outcomes at "iso-O2 saturation" due to reduced ventilatory requirements. Physiological benefits derived from O2 supplementation are thus likely primary drivers of dyspnea relief and improved exercise tolerance on NHFO2 (vs air) in these patients.
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