Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Evaluation of Rituximab Versus Approved Therapies in Aquaporin-4-IgG-Positive Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Network Meta-analysis.

Neurology and therapy·2026
Same author

Challenges and future directions for multiple sclerosis after the 2024 McDonald diagnostic criteria.

Nature medicine·2026
Same author

Corrigendum to "A Pre-symptomatic phase of tumefactive multiple sclerosis mirrors radiologically isolated syndrome" [Multiple Sclerosis and Related Disorders 112 (2026) 107312].

Multiple sclerosis and related disorders·2026
Same author

Socioeconomic status in Behçet's syndrome.

Clinical and experimental rheumatology·2026
Same author

Efficacy and Safety of Patients With Relapsing Multiple Sclerosis Switching to Ocrelizumab Due to Suboptimal Treatment Response: Results of the 4-Year CASTING-LIBERTO Trial.

European journal of neurology·2026
Same author

A Pre-symptomatic phase of tumefactive multiple sclerosis mirrors radiologically isolated syndrome.

Multiple sclerosis and related disorders·2026

Related Experiment Video

Updated: Apr 11, 2026

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

2.2K

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using

Bade Gulec1, Elif Everest1, Melih Tutuncu1

  • 1Department of Neurology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkiye.

Annals of Clinical and Translational Neurology
|April 10, 2026
PubMed
Summary

Antibody-negative atypical inflammatory demyelinating disorders (AIDD) are diverse. Unsupervised clustering identified three distinct AIDD phenotypes, aiding classification and future research in CNS demyelination.

Keywords:
atypical demyelinating disordersdouble‐seronegative disordersprincipal component analysesunsupervised clustering

More Related Videos

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

7.9K
Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
08:49

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

2.6K

Related Experiment Videos

Last Updated: Apr 11, 2026

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

2.2K
Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

7.9K
Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
08:49

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

2.6K

Area of Science:

  • Neurology
  • Immunology
  • Clinical Research

Background:

  • Central nervous system (CNS) inflammatory demyelinating syndromes like MS, AQP4+ NMOSD, and MOGAD can overlap.
  • Some patients present with atypical features and are double-seronegative, challenging current diagnostic classifications.

Purpose of the Study:

  • To characterize the phenotypic spectrum of antibody-negative atypical inflammatory demyelinating disorders (AIDD).
  • To utilize unsupervised clustering for refining the classification of these challenging cases.

Main Methods:

  • Retrospective analysis of 316 patients with CNS demyelinating disorders.
  • Application of principal component analysis and k-means clustering to 80 AIDD cases.
  • Inclusion of clinical, demographic, and radiological data for clustering.

Main Results:

  • AIDD patients exhibited lower disability and fewer lesions in specific brain regions compared to MS and NMOSD.
  • Three distinct AIDD clusters emerged: myelitis-predominant, brainstem-dominant, and optic neuritis-dominant.
  • Treatment patterns varied, with rituximab being the most common therapy.

Conclusions:

  • Double-seronegative AIDD is a heterogeneous group requiring refined classification.
  • Unsupervised clustering offers a data-driven approach to phenotype classification.
  • This framework may facilitate biomarker discovery and therapeutic development for antibody-negative CNS demyelination.