Related Experiment Video
Updated: Apr 11, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
A Cross-sectional Study of Skin Prick Test to Aspergillus Antigen in Asthmatic Patients and Their Correlation with
K R Guna1, Jereen Varghese, Nithin Thomas
1Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Chengalpet, Tamil Nadu, India.
Context:
This study aimed to determine the prevalence of Aspergillus antigen sensitization using the Skin Prick Test (SPT) among asthmatic patients and to evaluate its correlation with disease severity using spirometry.
Aims:
This study aimed to determine the prevalence of Aspergillus antigen sensitization using the SPT among asthmatic patients and to evaluate its correlation with disease severity using spirometry.
Settings And Design:
A cross-sectional study was conducted in the Department of Respiratory Medicine, Shri Sathya Sai Medical College, involving 102 asthmatic patients.
Subjects And Methods:
Participants underwent SPT for Aspergillus fumigatus and Aspergillus niger. Spirometry assessed Forced Expiratory Volume in 1 s (FEV1) and FEV1/Forced Vital Capacity ratio.
Statistical Analysis Used:
Data were analyzed using SPSS 29, with P < 0.05 considered statistically significant.
Results:
The study analyzed 102 asthma patients, predominantly aged 20-40 years (73.5%) and male (64.7%). Normal body mass index was observed in 43.1%, while 34.3% were overweight. Asthma duration was <5 years in 48% of participants. Positive SPTs were found in 65.7%, with a significant correlation between wheal size and SPT results (P < 0.001). Spirometry revealed mild, moderate, and severe impairments in 40.2%, 30.4%, and 29.4%, respectively, with SPT positivity significantly associated with lung function impairment (P = 0.003). No significant associations were noted between SPT results and demographics, asthma duration, histamine, or saline response.
Conclusions:
This study highlights the high prevalence of Aspergillus sensitization among asthmatic patients, which is significantly associated with reduced lung function. The findings highlight the importance of incorporating SPTs in routine asthma management to identify Aspergillus sensitization early.
More Related Videos
Related Concept Videos
01:30Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:24Asthma-III: Symptoms and Complications
Classification of Asthma
01:26Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
01:29Asthma-I: Introduction
01:20Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.