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Updated: Apr 11, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Memory and Resting-State Connectivity in Acute Transient Global Amnesia: A Case-Control fMRI Study.

Elias El Otmani¹, Emmanuel Barbeau², Béatrice Lemesle³

¹ToNIC, Toulouse NeuroImaging Center, UMR 1214, Universit. De Toulouse, INSERM, Paul Sabatier University (UT3), Toulouse, France.

Annals of Clinical and Translational Neurology

|April 10, 2026

Summary

This summary is machine-generated.

Transient global amnesia (TGA) involves temporary memory loss due to reduced connectivity in the episodic memory network. This condition, characterized by anterograde amnesia, resolves within three months, sparing semantic memory.

Keywords:

episodic memory memory networks transient global amnesia

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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

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Published on: August 5, 2014

Area of Science:

Neuroscience
Cognitive Neurology
Neuroimaging

Background:

Transient global amnesia (TGA) presents as isolated amnesia, with debated network-level mechanisms and neuropsychological profiles.
Hippocampal lesions are known, but the broader functional network involvement requires further characterization.

Purpose of the Study:

To characterize the functional and neuropsychological correlates of acute TGA.
To investigate the longitudinal evolution of these correlates over three months.

Main Methods:

A prospective case-control study involving 20 TGA patients and 20 healthy controls.
Neuropsychological testing and structural/functional MRI were performed at acute, day 3, and 3-month follow-up.
Analysis focused on episodic, semantic, and metamemory domains, and resting-state fMRI connectivity within the episodic memory network and large-scale brain networks.

Main Results:

TGA patients exhibited profound, isolated anterograde amnesia in the acute phase, which resolved by 3 months.
Acute-phase MRI revealed hypoconnectivity within the extended hippocampal system (parahippocampal-cingulate cortices), normalizing by 3 months.
Small bilateral lesions were noted in TGA patients; semantic memory and metamemory remained intact.

Conclusions:

TGA is linked to transient, selective hypoconnectivity within the mesiotemporal-cingulate episodic memory network.
The study clarifies the recovery time course of anterograde amnesia and confirms preserved semantic memory and metamemory.
TGA appears to be a transient limbic dysconnectivity syndrome, not a diffuse network disorder.