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Updated: Apr 11, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Antibiotic stewardship in long-term care facilities]
Andy Prost-A-Petit1, Caroline Bastid1, Julien Le Breton2
1Service de médecine interne de la personne âgée, Département de réadaptation et gériatrie, Hôpitaux universitaires de Genève, 1211 Genève 14.
Abstract:
The appropriate use of antibiotics is a major public health issue. Long-term care facilities (LTCF) have an increased risk of infection in a vulnerable population. The SPOT 2025 survey revealed that 2.6 % of Swiss LTCF residents were taking antibiotics, rising to 5.9 % in the French-speaking region. To improve the prescription of antibiotics in nursing homes, the application of the revised McGeer criteria and the judicious use of diagnostic tests should be reinforced, particularly for urinary, respiratory, and skin infections, along with hygiene and infection prevention measures. Multimodal interventions (guidelines, training, feedback) can reduce overall antibiotic use by 14 % and should be assimilated and contextualized in nursing homes.
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