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Reconsidering cytoreductive therapy in high-risk pediatric mastocytosis: From diffuse cutaneous to smoldering
Mara Giavina-Bianchi1,2, Marina França de Paula Santos1, Alessandra Tellian Jacob1
1Clinical Immunology and Allergy Division, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
The Journal of Allergy and Clinical Immunology. Global
|April 10, 2026
Abstract:
Pediatric mastocytosis is usually benign and self-limiting, but diffuse cutaneous forms carry a higher risk of fatal anaphylaxis and/or underlying systemic disease. Cytoreductive treatment can modify the prognosis in these patients.
Keywords:
Diffuse cutaneous mastocytosischildhoodcytoreductive treatmentfatal anaphylaxismidostaurinpediatricssystemic mastocytosisMore Related Videos
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