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Related Experiment Video

Updated: Apr 11, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Cognitive dysfunction in patients with interstitial lung disease.

Xiaojun Deng¹, Xingquan Xiong^2,3, Yuyan Liu^2,4

¹Department of Critical Care Medicine, Shanghai Sixth People's Hospital, Shanghai, China.

Frontiers in Medicine

|April 10, 2026

Summary

This summary is machine-generated.

Interstitial lung disease (ILD) is linked to cognitive impairment, with lung tissue showing transcriptomic changes overlapping with brain function pathways. Further research into this lung-brain axis is crucial for patient management.

Keywords:

Mini-Mental State Examination RNA sequencing cognitive dysfunction interstitial lung disease lung-brain axis

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Published on: December 19, 2020

Area of Science:

Pulmonary Medicine
Neuroscience
Genomics

Background:

Interstitial lung disease (ILD) affects lung function and may impact cognitive status.
Understanding the molecular mechanisms underlying potential lung-brain interactions in ILD is essential.

Purpose of the Study:

To investigate cognitive function in ILD patients compared to controls.
To analyze lung tissue transcriptomic alterations in ILD.
To explore potential lung-brain interaction mechanisms and clinical implications.

Main Methods:

Compared Mini-Mental State Examination (MMSE) scores between 45 ILD patients and 45 controls.
Performed RNA sequencing on lung tissue from 29 ILD cases and 14 non-diseased controls.
Utilized PCA, differential gene expression analysis, and Gene Ontology (GO) enrichment analysis.

Main Results:

ILD patients exhibited significantly lower MMSE scores, particularly in attention and orientation.
Transcriptomic analysis revealed distinct separation between ILD and control lung tissue.
Identified 1,544 differentially expressed genes (DEGs) and enrichment for inflammatory, fibrotic, and nervous system pathways.

Conclusions:

Preliminary evidence suggests a link between ILD and cognitive impairment.
Overlapping transcriptomic alterations in lung tissue support a potential lung-brain axis in ILD.
Highlights the need to consider cognitive health in ILD management and warrants further investigation.