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Published on: August 4, 2021
Predictive value of fibrinogen-to-albumin ratio in early missed miscarriage: a case-control study
Wenhua Liu1, Shanshan Tang1, Miao Deng1
1Department of Obstetrics and Gynecology, Hangzhou Women's Hospital, Hangzhou, China.
Background:
Currently, an increasing amount of evidence highlights the significant role that prothrombotic conditions play in the occurrence of early missed miscarriage.
Objective:
In this research project, our objective was to investigate the predictive function of the fibrinogen-to-albumin ratio (FAR) in patients with early missed miscarriage.
Methods:
In this study, a total of 180 women were enrolled, comprising 90 women who experienced early missed miscarriage and 90 women with normal pregnancies who chose to undergo elective abortion. A thorough comparison was made between the missed miscarriage group and the control group regarding demographic characteristics and several routine blood parameters, including fibrinogen, albumin, D-dimer, the fibrinogen-to-albumin ratio (FAR), the neutrophil-to-lymphocyte ratio (NLR), platelet count (PLT), the platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV). Subsequently, receiver operating characteristic (ROC) curve analysis was performed to assess and quantify the predictive capacity of these parameters.
Results:
No significant discrepancies were observed in albumin, D-dimer, mean platelet volume (MPV), platelet count (PLT), and platelet-to-lymphocyte ratio (PLR) between the two cohorts (p > 0.05). Conversely, the neutrophil-to-lymphocyte ratio (NLR), fibrinogen, and the fibrinogen-to-albumin ratio (FAR) were elevated in the early missed miscarriage group compared with the control group (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed that the NLR exhibited a sensitivity of 71.1% and a specificity of 74.4% with a cutoff value of 3.58, whereas the FAR exhibited a sensitivity of 90% and a specificity of 81.1% with a cutoff value of 0.008 for predicting missed miscarriage.
Conclusion:
Our research findings indicated that the FAR and NLR are effective parameters for predicting missed miscarriage, as demonstrated by their respective sensitivity and specificity.
