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Multiple Allele Traits

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Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Hardy-Weinberg Principle

Hardy-Weinberg Principle

Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.

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Related Experiment Video

Updated: Apr 11, 2026

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

Identifying Inheritance Patterns of Allelic Imbalance, using Integrative Modeling and Bayesian Inference.

Stephanie H Hoyt, Timothy E Reddy, Raluca Gordân

Biorxiv : the Preprint Server for Biology

|April 10, 2026

Summary

This summary is machine-generated.

This study introduces a Bayesian method to analyze allele-specific expression (ASE) and chromatin accessibility across multiple family trios. This approach improves the detection of genetic variants influencing traits and their inheritance patterns.

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Last Updated: Apr 11, 2026

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

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Published on: December 10, 2012

In Vivo Modeling of the Morbid Human Genome using Danio rerio

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Published on: August 24, 2013

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Area of Science:

Genomics
Molecular Biology
Bioinformatics

Background:

Interpreting the impact of novel mutations on phenotypic traits, especially cis-regulatory variants, is complex.
Allelic imbalance, common in rare variants, offers a way to infer inheritance patterns in genetic studies.
Existing allele-specific expression (ASE) methods often focus on single individuals, limiting insights.

Purpose of the Study:

To develop a joint inference method for analyzing allele-specific expression (ASE) and chromatin accessibility across multiple individuals in a trio.
To improve the estimation of ASE and identify its mode of inheritance simultaneously.
To enhance statistical power and quantify uncertainty in genetic analyses of phenotypic traits.

Main Methods:

A Bayesian approach for joint inference across multiple individuals in a trio.
Simultaneous estimation of ASE and identification of inheritance modes.
Application to ATAC-seq and RNA-seq data from several trios.

Main Results:

The joint inference method improves statistical power by aggregating information across individuals.
The model successfully estimates uncertainty and ranks inheritance modes by posterior probability.
Demonstrated applicability to allele-specific chromatin accessibility, linking ASE to chromatin state and potential causal variants.

Conclusions:

Joint analysis of related individuals enhances the understanding of genetic effects on gene regulation.
This methodology facilitates the routine collection of family trio data for genetic studies.
Improved interpretation of cis-regulatory variants and their contribution to phenotypic variation.