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Explainable and reproducible AI: culturally responsive AI for health equity in minoritized groups
Michelle King-Okoye1,2, Harriett Fuller2,3, Kuan Tan1
1Adelaide University, Adelaide, SA, Australia.
Frontiers in Digital Health
|April 10, 2026
Summary
Artificial intelligence (AI) in healthcare requires explainable AI (XAI) for reliable diagnostics and treatments. Ensuring AI promotes health equity involves culturally responsive frameworks to address bias and promote reproducibility.
Area of Science:
- Healthcare technology
- Artificial intelligence
- Health equity
Background:
- Artificial intelligence (AI) offers transformative potential in healthcare, enhancing diagnostics, personalizing treatments, and improving operational efficiency.
- AI excels at identifying complex data patterns, potentially aiding clinical decision-making for faster diagnoses and tailored treatments.
- However, AI model consistency, reliability, and validation across diverse populations and settings are crucial for equitable healthcare delivery.
Purpose of the Study:
- To explore key considerations for ensuring AI promotes health equity in marginalized communities.
- To address the challenge of AI model interpretability, often described as "black boxes" in complex applications.
- To build on existing work in humanitarian and climate AI contexts regarding anticipatory health action.
Main Methods:
- This commentary explores the critical need for explainability and reproducibility in clinical AI models.
- It emphasizes embedding these features within culturally responsive frameworks to mitigate bias.
- The discussion draws parallels with anticipatory health action strategies in humanitarian and climate AI.
Main Results:
- Explainable AI (XAI) provides crucial insights into AI model predictions, enhancing trust and understanding for medical professionals.
- Physicians generally prefer XAI over non-explainable AI models due to increased transparency.
- Addressing historical and structural bias is essential for equitable AI implementation.
Conclusions:
- Achieving health equity through AI necessitates embedding explainability and reproducibility.
- Culturally responsive frameworks are vital to counteract bias in AI algorithms and their application.
- XAI is a critical component for trustworthy and equitable AI in diverse healthcare settings.
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