Related Experiment Video

Updated: Apr 11, 2026

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
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Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

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Effect of sugammadex on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic

Long Tian1, Yan Wang2, Yijie Bu2

  • 1Department of Thoracic Surgery/Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Oncology
|April 10, 2026
PubMed
Abstract

Insights

Sugammadex significantly reduces postoperative pulmonary complications (PPCs) after video-assisted thoracoscopic surgery (VATS) lung resection, especially atelectasis. This finding suggests sugammadex is a valuable option for improving patient outcomes in VATS procedures.

Area of Science:

  • Anesthesiology
  • Thoracic Surgery
  • Critical Care Medicine

Background:

  • Postoperative pulmonary complications (PPCs) are frequent following video-assisted thoracoscopic surgery (VATS) lung resection.
  • The efficacy of sugammadex in mitigating PPCs compared to traditional antagonists remains unclear.
  • This meta-analysis investigates the impact of sugammadex on PPCs in VATS pulmonary resection patients.

Purpose of the Study:

  • To evaluate the effectiveness of sugammadex in reducing overall PPCs after VATS pulmonary resection.
  • To compare the incidence of PPCs between sugammadex and traditional neuromuscular reversal agents.
  • To analyze the impact of sugammadex on specific types of PPCs, including atelectasis and pneumonia.

Main Methods:

  • A systematic meta-analysis adhering to PRISMA 2020 guidelines.
  • Searched major databases (PubMed, Web of Science, Cochrane Library, CNKI) up to December 13, 2024.
  • Included RCTs and cohort studies comparing sugammadex with other antagonists in VATS pulmonary resection, assessing overall PPCs as the primary outcome.

Main Results:

  • Nine studies with 2,240 patients were analyzed.
  • Sugammadex significantly reduced overall PPCs compared to control agents (OR = 0.68, 95% CI: 0.58-0.80, P < 0.001).
  • A notable decrease in atelectasis risk was observed with sugammadex (OR = 0.61, 95% CI: 0.47-0.80, P < 0.001), with no significant difference for pneumonia.

Conclusions:

  • Sugammadex demonstrates efficacy in reducing PPCs, particularly atelectasis, in patients undergoing VATS pulmonary resection.
  • The findings support sugammadex as a beneficial agent for improving outcomes in this patient population.
  • Further large-scale, high-quality research is recommended to confirm these results.
Keywords:
atelectasismeta-analysispostoperative pulmonary complicationsugammadexvideo-assisted thoracoscopic lung surgery

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