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The Clinical Impact of Concomitant Hemi-Arch Reconstruction at the time of Aortic Root Replacement
Parth M Patel1, Dov Levine2, Andy Dong1
1Division of Cardiothoracic Surgery, Department of Surgery, Emory University School of Medicine, Atlanta, Ga.
Insights
Concomitant hemi-arch aortic reconstruction during aortic root replacement increases stroke and in-hospital mortality risks. Careful patient selection is crucial for optimal outcomes in complex aortic surgeries.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Aortic Surgery
Background:
- The clinical significance of combining hemi-arch aortic reconstruction with aortic root replacement remains unclear.
- This study addresses the impact of concomitant hemi-arch aortic reconstruction during aortic root replacement procedures.
Purpose of the Study:
- To evaluate the clinical outcomes of aortic root replacement with and without concomitant hemi-arch aortic reconstruction.
- To compare in-hospital mortality and other adverse events between the two surgical approaches.
Main Methods:
- A multi-institutional retrospective study involving 1869 patients from 2004-2021.
- Propensity score matching created 698 pairs comparing aortic root replacement/hemi-arch aortic reconstruction with aortic root replacement/ascending aorta.
- Primary endpoint was in-hospital mortality.
Main Results:
- Concomitant hemi-arch aortic reconstruction led to longer bypass and crossclamp times.
- Higher rates of intra-aortic balloon pump support (6.3% vs 2.4%) and permanent neurologic dysfunction (4.5% vs 2.2%) were observed.
- In-hospital mortality was significantly higher in the concomitant hemi-arch aortic reconstruction group (5.0% vs 2.6%).
Conclusions:
- Both aortic root replacement/ascending aorta and concomitant hemi-arch aortic reconstruction yield excellent clinical outcomes.
- Concomitant hemi-arch aortic reconstruction is associated with increased risks of postoperative stroke and in-hospital mortality.
- Individualized patient assessment is essential for deciding on concomitant hemi-arch aortic reconstruction during aortic root replacement.
Objective:
The significance of concomitant hemi-arch aortic reconstruction in the setting of aortic root replacement is largely unknown. In this first multi-institutional study, the clinical impact of concomitant hemi-arch aortic reconstruction at the time of aortic root replacement was reviewed.
Methods:
From 2004 to 2021, 1869 patients underwent aortic root replacement and ascending aorta replacement at 2 major academic centers: 1116 with concomitant hemi-arch aortic reconstruction (aortic root replacement/hemi-arch aortic reconstruction) and 753 without hemi-arch aortic reconstruction (aortic root replacement/ascending aorta). Procedure and propensity score matching resulted in 698 pairs, which were compared. The primary end point was in-hospital mortality.
Results:
Mean age at operation was 56.8 ± 14.7 years and similar between groups (P = .984). Median cardiopulmonary bypass time (P < .001) and aortic crossclamp time (P < .001) were longer for aortic root replacement/hemi-arch aortic reconstruction. Patients receiving aortic root replacement/hemi-arch aortic reconstruction were more likely to need intra-aortic balloon pump support postoperatively (6.3% [44] vs 2.4% [17], P < .001). Permanent neurologic dysfunction occurred in 31 patients (4.5%) undergoing aortic root replacement/hemi-arch aortic reconstruction and 15 patients (2.2%) undergoing aortic root replacement/ascending aorta (P = .02). In-hospital mortality for patients receiving aortic root replacement/hemi-arch aortic reconstruction was 5.0% (35) and 2.6% (18) for patients receiving aortic root replacement/ascending aorta (P = .02). Ten-year survival was 79% versus 74% for hemi-arch aortic reconstruction versus aortic root replacement groups, respectively (P = .06).
Conclusions:
Clinical outcomes after both aortic root replacement/ascending aorta or with concomitant hemi-arch aortic reconstruction are excellent. Concomitant hemi-arch aortic reconstruction was associated with a higher rate of postoperative stroke and in-hospital mortality. The decision to perform hemi-arch aortic reconstruction at the time of aortic root replacement should be considered carefully and must be individualized in a patient-specific manner for optimal outcomes.
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