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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Structure and Function of Platelets01:18

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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Updated: Apr 11, 2026

Microfluidics in Assessing Platelet Function
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Pre-Transfusion Platelet Counts and Bleeding in Very Low Birth Weight Infants.

Ravi Patel1, Elizabeth Stone2, Rebecca Birch

  • 1Emory University School of Medicine and Children's Healthcare of Atlanta.

Research Square
|April 10, 2026
PubMed
Summary

Platelet transfusion thresholds for premature infants are inconsistent. This study found similar pre-transfusion platelet counts in very low birth weight infants with or without bleeding, except for those with severe intraventricular hemorrhage.

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Area of Science:

  • Neonatal Medicine
  • Hematology
  • Pediatric Critical Care

Background:

  • Platelet transfusion thresholds for very low birth weight (VLBW) infants (<1500g) lack standardization.
  • The impact of bleeding on these transfusion thresholds remains unclear.

Purpose of the Study:

  • To investigate pre-transfusion platelet counts in VLBW infants with and without bleeding.
  • To determine if bleeding influences platelet transfusion decisions in this population.

Main Methods:

  • Observational birth cohort study of 210 VLBW infants across 7 US hospitals.
  • Mixed-effects linear regression models analyzed pre-transfusion platelet counts.
  • Data focused on infants receiving at least one platelet transfusion within the first three weeks of life.

Main Results:

  • Most transfused VLBW infants (76%) experienced bleeding, primarily intraventricular hemorrhage (IVH, 61%).
  • Pre-transfusion platelet counts did not significantly differ between infants with and without bleeding (56.3 vs 58.5x10^3/µL).
  • Infants with severe IVH exhibited higher pre-transfusion platelet counts (68.9x10^3/µL) compared to the overall cohort (53.5x10^3/µL).

Conclusions:

  • Pre-transfusion platelet counts are similar in VLBW infants with or without diagnosed bleeding.
  • Severe intraventricular hemorrhage is associated with higher pre-transfusion platelet counts in VLBW infants.
  • Current findings suggest bleeding status may not be the sole determinant of platelet transfusion thresholds in VLBW infants.