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Updated: Apr 11, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Pre-Transfusion Platelet Counts and Bleeding in Very Low Birth Weight Infants
Ravi Patel1, Elizabeth Stone2, Rebecca Birch
1Emory University School of Medicine and Children's Healthcare of Atlanta.
Objective:
Platelet transfusion thresholds for very low birth weight (VLBW, <1500g) infants vary widely, and the role of bleeding on platelet transfusion thresholds is unknown.
Study Design:
This observational birth cohort study of VLBW infants born in 7 hospitals across the US examined pre-transfusion platelet counts in infants with and without bleeding who received at least 1 platelet transfusion in the first 3 weeks of life using mixed effect linear regression models.
Results:
Of the 210 transfused infants, most (76%) had bleeding; intraventricular hemorrhage (IVH) was the most common (61%) bleeding type. Pre-transfusion platelet counts were not different among infants with or without bleeding diagnoses (56.3 vs 58.5×103/μL, respectively; P=0.7). However, infants with severe IVH had higher platelet counts (68.9×103/μL) compared to the entire cohort (53.5×103/μL, P=0.01).
Conclusion:
Infants with or without bleeding diagnoses had similar pre-transfusion platelet counts; infants with severe IVH had higher pre-transfusion platelet counts.
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