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Identification of Hub genes in melasma using integrated transcriptomic analysis.

Akhtar Veg1, Mohd Murshad Ahmed2, Rafat Ali3

  • 1Centre for Interdisciplinary Research in Basic Sciences (CIRBSc), Jamia Millia Islamia, New Delhi-110025, India.

Bioinformation
|April 10, 2026
PubMed
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Understanding melasma pathogenesis is key for effective treatment. Transcriptomics reveal oxidative stress, inflammation, and dermal remodeling pathways involved in this common hyperpigmentation skin condition.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Genomics

Background:

  • Melasma is a common facial hyperpigmentation disorder.
  • Current management is challenging due to incomplete understanding of its pathogenesis.
  • Identifying molecular mechanisms is crucial for developing targeted therapies.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying melasma pathogenesis.
  • To identify key genes and pathways involved in melasma development.
  • To provide insights for potential therapeutic targets.

Main Methods:

  • Integrated analysis of microarray datasets.
  • Transcriptomics studies to identify gene expression patterns.
  • Pathway analysis to determine molecular mechanisms.
Keywords:
DEGsHub genesMelasmagene expression profilingtranscriptomic analysis

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Main Results:

  • Melasma involves complex, multifactorial molecular mechanisms.
  • Key pathways identified include oxidative stress, inflammatory signaling, and dermal remodeling.
  • Transcriptomic data highlights specific genes and pathways contributing to hyperpigmentation.

Conclusions:

  • Oxidative stress, inflammation, and dermal remodeling are critical in melasma.
  • Potential therapeutic targets include DNA repair regulators and metabolic stabilizers.
  • Further research into these pathways can advance melasma treatment strategies.