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Effect of chronic stress on human endocrine function: A biomarker-based study
Ajeet Singh1, Pramod Kumar1, Hemali Jha2
1Department of Physiology, Santosh Medical College, Ghaziabad, Uttar Pradesh, India.
Bioinformation
|April 10, 2026
Summary
Chronic stress significantly disrupts endocrine function, altering cortisol, thyroid, and sex hormones. Thyroid-stimulating hormone (TSH) shows potential for monitoring these stress-related changes.
Area of Science:
- Endocrinology
- Stress Physiology
- Hormone Regulation
Background:
- Chronic stress is a pervasive issue with significant health implications.
- Endocrine function, involving key hormones like cortisol, thyroid, and sex hormones, is sensitive to stress.
- Understanding these impacts is crucial for public health.
Purpose of the Study:
- To investigate the impact of chronic stress on endocrine function.
- To examine alterations in cortisol, thyroid hormones, and sex hormones.
- To identify potential biomarkers for stress-related endocrine dysfunctions.
Main Methods:
- Cross-sectional study design.
- Inclusion of 120 participants aged 18-60.
- Assessment of individuals exposed to chronic stress for at least 6 months.
Main Results:
- Elevated cortisol levels were observed in participants under chronic stress.
- Disruptions in thyroid and reproductive hormone levels were noted.
- Higher stress levels correlated with more pronounced hormonal imbalances.
Conclusions:
- Chronic stress plays a significant role in hormone dysregulation.
- Biomarkers such as thyroid-stimulating hormone (TSH) may aid in monitoring stress-induced endocrine changes.
- Findings offer insights for early detection and therapeutic interventions for stress-related health issues.
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