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Related Experiment Video

Updated: Apr 11, 2026

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
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Minimally required essential bio markers for lymphoma.

Shikha Ghanghoria1, Arvind Ghanghoria2, Gulladurthi Prudhvi Sai Chownika1

  • 1Department of Pathology MGMMC MYH, Indore, Madhya Pradesh, India.

Bioinformation
|April 10, 2026
PubMed
Summary

Identifying essential immunohistochemical (IHC) markers is crucial for classifying and predicting outcomes in lymphoma. This study recommends a cost-effective IHC panel for reliable lymphoma diagnosis, especially in resource-limited settings.

Keywords:
B-cell markersKi-67Lymphomaimmunohistochemistryt-cell markers

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Area of Science:

  • Hematology
  • Oncology
  • Immunohistochemistry

Background:

  • Lymphoma encompasses diverse blood cancers with varied characteristics.
  • Accurate classification and prognostication require precise diagnostic markers.
  • Identifying essential immunohistochemical (IHC) markers is critical for lymphoma management.

Purpose of the Study:

  • To determine a minimum essential panel of IHC markers for lymphoma classification and prognostication.
  • To establish a cost-effective diagnostic approach for lymphoid malignancies.

Main Methods:

  • A retrospective study analyzed 88 lymphoma cases.
  • A primary panel of monoclonal antibodies including CD3, CD5, CD20, CD10, CD45, PAX-5, and Ki-67 was utilized.
  • Immunohistochemical staining was performed to assess marker expression.

Main Results:

  • B-cell lymphomas showed high labeling with CD20, CD45, and PAX-5.
  • T-cell lymphomas were strongly positive for CD3 and CD5.
  • Aggressive subtypes like Diffuse Large B-Cell Lymphoma exhibited high Ki-67 proliferation indices.

Conclusions:

  • A restricted panel of IHC markers can reliably diagnose and prognosticate lymphoma.
  • This approach is particularly beneficial for resource-limited settings.
  • The study provides recommendations for an essential IHC marker panel for lymphoma.