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Updated: Apr 11, 2026

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles
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Polydopamine-based Surface Modifications for Tissue Engineering and Biosensing: From Understanding Chemistry to

Joya Nath1, Rachel Philips1, Joel Pilli1,2

  • 1Sustainable Manufacturing and Tissue Engineering Laboratory, Department of Materials and Metallurgical Engineering, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA.

JOM (Warrendale, Pa. : 1989)
|April 10, 2026
PubMed
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Polydopamine (PDA), inspired by mussel adhesion, is a versatile biomaterial. This review highlights PDA

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Polydopamine (PDA) is a biomaterial inspired by mussel adhesive proteins.
  • PDA is synthesized from dopamine, a common neurotransmitter.
  • Its adhesive properties stem from catechol and amine groups, enabling versatile surface coating.

Purpose of the Study:

  • To review 17 years of research on polydopamine (PDA).
  • To examine PDA applications, especially in the biomedical field.
  • To explore the potential of 3D printing and biosensor integration with PDA.

Main Methods:

  • Literature review of polydopamine research from 2007 to the present.
  • Analysis of PDA's chemical properties and adhesion mechanisms.

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Last Updated: Apr 11, 2026

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  • Synthesis of findings on PDA's applications in various biomedical domains.

    • Main Results:

    • PDA exhibits robust adhesion and enhances surface properties like bioactivity and mechanical strength.
    • PDA demonstrates significant potential in tissue engineering (bone, neural, cardiac), drug delivery, and biosensing.
    • PDA-coated 3D-printed scaffolds show biocompatibility and osteogenic potential.

    Conclusions:

    • Polydopamine is a powerful biomaterial with diverse biomedical applications.
    • Integrating PDA with 3D printing and biosensors can expand its manufacturing potential.
    • PDA offers innovative solutions for regenerative medicine, targeted therapies, and diagnostics.