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KBr-enabled electrochemical transformation of alkynes into α-bromoketones/1,2-diketones
Yulin Li1, Siyu Lei2, Yuexia Zhang1
1College of Chemistry and Chemical Engineering, Qingdao University, 308 Ningxia Road, Qingdao 266071, China. zhangyx@qdu.edu.cn.
Abstract:
In recognition of the crucial role of ketone motifs in significant organic transformations and the synthesis of valuable molecules (e.g., pharmaceuticals, pesticides, and fine chemicals), we herein report an electrochemical protocol for the synthesis of α-bromoketones and 1,2-diketones from alkynes. This method employs safe and cost-effective KBr as both the bromine source and supporting electrolyte, while NFSI acts as an electron acceptor and MeOH serves as the solvent. The transformation proceeds smoothly, delivering the desired products in good yields.
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