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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.5K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

657
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
657
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

873
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Tumor Progression02:07

Tumor Progression

7.9K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.9K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

2.9K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
2.9K

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Related Experiment Video

Updated: Apr 11, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

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Ulcerative Colitis-Associated Neoplasia.

Gilad Alon1, Stefan Holubar

  • 1Department of Colon and Rectal Surgery, Cleveland Clinic, Cleveland, Ohio.

Diseases of the Colon and Rectum
|April 10, 2026
PubMed
Summary

A man with ulcerative colitis developed colon cancer, requiring surgery and chemotherapy. He is now preparing for a potential ileal pouch-anal anastomosis reconstruction.

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Colorectal Surgery

Background:

  • A 58-year-old male with a 20-year history of ulcerative colitis (UC) presented with symptoms of large bowel obstruction.
  • Colonoscopy revealed a partial obstructing splenic flexure mass, with quiescent colitis elsewhere, despite treatment with ustekinumab.

Purpose of the Study:

  • To report a case of colonic adenocarcinoma in a patient with a long history of ulcerative colitis.
  • To discuss the management of colonic adenocarcinoma in the context of inflammatory bowel disease.

Main Methods:

  • Laparoscopic total abdominal colectomy with end ileostomy was performed for the colonic adenocarcinoma.
  • Staging workup, including imaging and carcinoembryonic antigen (CEA) levels, was conducted.
  • Adjuvant chemotherapy was recommended due to high-risk pathological features.
Keywords:
Colon cancerDysplasiaIleoanal pouchRectal cancerUlcerative colitis

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Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
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Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS
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Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
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Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS
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Main Results:

  • Pathology confirmed pT3N0 colonic adenocarcinoma with obstruction and microscopic lymphovascular invasion.
  • No metastatic disease was detected during staging.
  • The patient expressed interest in ileal pouch-anal anastomosis (IPAA) after completing chemotherapy.

Conclusions:

  • Colonic adenocarcinoma can occur in patients with ulcerative colitis, even with quiescent disease.
  • Multidisciplinary management is crucial for optimizing outcomes in these complex cases.
  • Further evaluation for IPAA is planned after neoadjuvant therapy.